FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Acc1
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General Information
Symbol
Dmel\Acc1
Species
D. melanogaster
Name
FlyBase ID
FBal0314168
Feature type
allele
Associated gene
Dmel\Acc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Sasamura et al., 2013)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q359term.

(Sasamura et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:7,980,895..7,980,895 [-]
Nucleotide change:

C7980895T

Amino acid change:

Q518term | ACC-PA; Q359term | ACC-PB; Q359term | ACC-PC; Q384term | ACC-PE; Q359term | ACC-PF; Q359term | ACC-PG

Reported amino acid change:

Q359term

Comment:

Mutation mapped relative to isoforms ACC-PB, PC, PF and PG. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Sasamura et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ACC1 mutant wing disc clones generated in a Minute background show significant tissue overgrowth. Overgrowth phenotypes are also seen when ACC1 mutant clones are generated in the posterior compartment of the wing disc. These are seen in the wing disc pouch and hinge regions but not in the notum region. Increased proliferation is seen compared to controls but apicobasal polarity is unaffected.

      (Sasamura et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      Acc1 has increased cell number | somatic clone phenotype, non-suppressible by Scer\GAL4hh.PU/laceUAS.Tag:HA

      (Sasamura et al., 2013)
      Phenotype Manifest In
      Suppressed by
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of laceScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hh.PU does not suppress the overgrowth phenotype seen in ACC1 mutant clones in the posterior compartment of the wing disc.

      Expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4sd.PU significantly suppresses the severity of overproliferation seen in ACC1 mutant wing disc clones, but does not reduce the frequency of discs exhibiting overgrowth.

      (Sasamura et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      AccB131

      (Sasamura et al., 2013)
      Rescued by

      Acc1 is rescued by AccUAS.cSa/Scer\GAL4hh.PU

      (Sasamura et al., 2013)
      Comments

      Expression of ACCScer\UAS.cSa under the control of Scer\GAL4hh.PU rescues the overgrowth phenotype seen in ACC1 mutant clones in the posterior compartment of the wing disc.

      (Sasamura et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ACC1
      (Amartuvshin et al., 2025, Sasamura et al., 2013)
      Acc1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)