FlyBase Allele Report: Hsap\GARS1[WT.UAS]

General Information

Symbol

Hsap\GARS1^WT.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0314806

Feature type

allele

Associated gene

Hsap\GARS1

Associated Insertion(s)

Carried in Construct

PBac{UAS-GARS.WT}

Key Links

Transgenic product class

cDNA

(Niehues et al., 2015)

wild_type

(Niehues et al., 2015)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Niehues et al., 2015)

wild_type

(Niehues et al., 2015)

Mutagen

in vitro construct

(Niehues et al., 2015)

Progenitor genotype

Carried in construct

PBac{UAS-GARS.WT}

Cytology

Description

UASt regulates expression of full-length wild type Hsap\GARS cDNA.

(Niehues et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\GARS1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Scer\GAL4^Act5C.PU

(Niehues et al., 2015)

viable, with Scer\GAL4^nSyb.PU

(Niehues et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^tub.PU-mediated expression from the adult stage onwards (achieved via the GAL80 target system) does not alter lifespan.

Scer\GAL4^VGlut-OK371-mediated expression does not impair motor performance in adults.

Scer\GAL4^VGlut-OK371-mediated expression does not affect the number of motor neuron cell bodies or neuromuscular junction morphology in the ventral nerve cord of third instar larvae.

Scer\GAL4^VGlut-OK371-mediated expression does not affect synapse size on any muscle analyzed (distal muscles 8 and 1/9; and proximal muscles 21 and 4).

(Niehues et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\GARS1^WT.UAS, Scer\GAL4^sca-109-68 is a suppressor of visible | adult stage phenotype of GlyRS^KK107421, Scer\GAL4^sca-109-68

(Mora et al., 2025)

Hsap\GARS1^WT.UAS, Scer\GAL4^VGlut1-OK371 is a suppressor of decreased rate of adult locomotory behavior phenotype of GlyRS^KK107421, Scer\GAL4^VGlut1-OK371

(Mora et al., 2025)

Hsap\GARS1^WT.UAS, Scer\GAL4^sca-109-68 is a suppressor of decreased size | adult stage phenotype of GlyRS^KK107421, Scer\GAL4^sca-109-68

(Mora et al., 2025)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\GARS1^WT.UAS, Scer\GAL4^sca-109-68 is a suppressor of scutellar bristle | absent phenotype of GlyRS^KK107421, Scer\GAL4^sca-109-68

(Mora et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\GARS1^WT.UAS

Hsap\GARS^WT.Scer\UAS

Hsap\GARS^WT.UAS

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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