FlyBase Allele Report: Dmel\GlyRS[KK107421]

General Information

Symbol

Dmel\GlyRS^KK107421

Species

D. melanogaster

Name

FlyBase ID

FBal0234924

Feature type

allele

Associated gene

Dmel\GlyRS

Associated Insertion(s)

Carried in Construct

P{KK107421}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK107421}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK107421

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by yki^{S168A.UAS.EGFP,Tag:HA}

(Yeom et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^ppk.PG

(Mora et al., 2025)

decreased rate of adult locomotory behavior, with Scer\GAL4^VGlut1-OK371

(Mora et al., 2025)

decreased size | adult stage, with Scer\GAL4^sca-109-68

(Mora et al., 2025)

visible | adult stage, with Scer\GAL4^sca-109-68

(Mora et al., 2025)

Phenotype Manifest In

dendrite | larval stage, with Scer\GAL4^ppk.PG

(Mora et al., 2025)

larval multidendritic class IV neuron, with Scer\GAL4^ppk.PG

(Mora et al., 2025)

scutellar bristle | absent, with Scer\GAL4^sca-109-68

(Mora et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

GlyRS^KK107421, Scer\GAL4^sca-109-68 has decreased size | adult stage phenotype, suppressible by Hsap\GARS1^K456Q.UAS, Scer\GAL4^sca-109-68

(Mora et al., 2025)

GlyRS^KK107421, Scer\GAL4^sca-109-68 has visible | adult stage phenotype, suppressible by Hsap\GARS1^WT.UAS, Scer\GAL4^sca-109-68

(Mora et al., 2025)

GlyRS^KK107421, Scer\GAL4^sca-109-68 has visible | adult stage phenotype, suppressible by Hsap\GARS1^K456Q.UAS, Scer\GAL4^sca-109-68

(Mora et al., 2025)

GlyRS^KK107421, Scer\GAL4^VGlut1-OK371 has decreased rate of adult locomotory behavior phenotype, suppressible by Hsap\GARS1^WT.UAS, Scer\GAL4^VGlut1-OK371

(Mora et al., 2025)

GlyRS^KK107421, Scer\GAL4^VGlut1-OK371 has decreased rate of adult locomotory behavior phenotype, suppressible by Hsap\GARS1^K456Q.UAS, Scer\GAL4^VGlut1-OK371

(Mora et al., 2025)

GlyRS^KK107421, Scer\GAL4^sca-109-68 has decreased size | adult stage phenotype, suppressible by Hsap\GARS1^WT.UAS, Scer\GAL4^sca-109-68

(Mora et al., 2025)

Suppressor of

Statement

Reference

GlyRS^KK107421, Scer\GAL4^GMR.PFa is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, yki^{S168A.UAS.EGFP,Tag:HA}

(Yeom et al., 2020)

GlyRS^KK107421, Scer\GAL4^GMR.PFa is a suppressor | partially of neoplasia | adult stage phenotype of Scer\GAL4^GMR.PFa, yki^{S168A.UAS.EGFP,Tag:HA}

(Yeom et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

GlyRS^KK107421, Scer\GAL4^sca-109-68 has scutellar bristle | absent phenotype, suppressible by Hsap\GARS1^WT.UAS, Scer\GAL4^sca-109-68

(Mora et al., 2025)

GlyRS^KK107421, Scer\GAL4^sca-109-68 has scutellar bristle | absent phenotype, suppressible by Hsap\GARS1^K456Q.UAS, Scer\GAL4^sca-109-68

(Mora et al., 2025)

Suppressor of

Statement

Reference

GlyRS^KK107421, Scer\GAL4^GMR.PFa is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PFa, yki^{S168A.UAS.EGFP,Tag:HA}

(Yeom et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v106748

P{KK107421}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Aats-gly^KK107421

GlyRS^KK107421

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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