FlyBase Allele Report: Dmel\PVRAP[HMJ23233]

General Information

Symbol

Dmel\PVRAP^HMJ23233

Species

D. melanogaster

Name

FlyBase ID

FBal0315488

Feature type

allele

Associated gene

Dmel\PVRAP

Associated Insertion(s)

Carried in Construct

P{TRiP.HMJ23233}

Also Known As

UAS-PVRAP^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMJ23233}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMJ23233

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by Ras85D^V12.UAS

(Martínez-Abarca Millán et al., 2023)

exacerbates carcinoma

modeled by Ras85D^V12.UAS

(Soler Beatty et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

PVRAP^HMJ23233, Ras85D^V12.UAS, Scer\GAL4^ap.PU has neoplasia | third instar larval stage phenotype, enhanceable by Egfrap^LS/Egfrap^LS

(Soler Beatty et al., 2021)

Enhancer of

Statement

Reference

PVRAP^HMJ23233, Scer\GAL4^ap-md544 is an enhancer of hyperplasia | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

PVRAP^HMJ23233, Scer\GAL4^ap.PU is an enhancer of neoplasia | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Scer\GAL4^ap.PU, PVRAP^HMJ23233 is an enhancer of neoplasia | third instar larval stage phenotype of Egfrap^LS, Ras85D^V12.UAS, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Other

Statement

Reference

PVRAP^HMJ23233, Scer\GAL4^ap-md544, by^33c has partially lethal - majority die phenotype

(Martínez-Abarca Millán et al., 2023)

PVRAP^HMJ23233, Scer\GAL4^ap-md544, by^33c has visible | adult stage phenotype

(Martínez-Abarca Millán et al., 2023)

Phenotype Manifest In

Enhanced by

Statement

Reference

PVRAP^HMJ23233, Ras85D^V12.UAS, Scer\GAL4^ap.PU has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by Egfrap^ΔSH2/Egfrap^ΔSH2

(Soler Beatty et al., 2021)

Enhancer of

Statement

Reference

PVRAP^HMJ23233, Scer\GAL4^ap-md544 is an enhancer of wing disc phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

PVRAP^HMJ23233, Scer\GAL4^ap.PU is an enhancer of wing disc dorsal compartment | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Scer\GAL4^ap.PU, PVRAP^HMJ23233 is an enhancer of wing disc dorsal compartment | third instar larval stage phenotype of Egfrap^LS, Ras85D^V12.UAS, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Other

Statement

Reference

PVRAP^HMJ23233, Scer\GAL4^ap-md544, by^33c has wing phenotype

(Martínez-Abarca Millán et al., 2023)

PVRAP^HMJ23233, Scer\GAL4^ap-md544, by^33c has scutum phenotype

(Martínez-Abarca Millán et al., 2023)

Egfrap^HMJ23378, PVRAP^HMJ23233, Scer\GAL4^ap.PU has wing phenotype

(Soler Beatty et al., 2021)

Egfrap^HMJ23378, PVRAP^HMJ23233, Scer\GAL4^ap.PU has external sensillum | increased number | adult stage phenotype

(Soler Beatty et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Egfrap^HMJ23378 and PVRAP^HMJ23233 under the control of Scer\GAL4^ap.PU leads to ectopic sensory organs in the notum and blisters in the wings.

(Soler Beatty et al., 2021)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

NIG-Fly

HMJ23233

y¹ v¹; P{TRiP.HMJ23233}attP40/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

PVRAP^HMJ23233

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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