FlyBase Allele Report: Dmel\sif[HMJ23517]

General Information

Symbol

Dmel\sif^HMJ23517

Species

D. melanogaster

Name

FlyBase ID

FBal0315632

Feature type

allele

Associated gene

Dmel\sif

Associated Insertion(s)

Carried in Construct

P{TRiP.HMJ23517}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMJ23517}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMJ23517

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodevelopmental disorder with language delay and seizures

CEC

(Lu et al., 2022)

model of cataract 48

CEA

(Ansar et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^da.G32

(Lu et al., 2022)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

(Lu et al., 2022)

abnormal neurophysiology | adult stage, with Scer\GAL4^GMR.PU

(Ansar et al., 2018)

decreased cell number | pupal stage, with Scer\GAL4^GMR.PU

(Ansar et al., 2018)

paralytic | heat sensitive, with Scer\GAL4^da.G32

(Lu et al., 2022)

paralytic | heat sensitive, with Scer\GAL4^elav.PU

(Lu et al., 2022)

partially lethal - majority die, with Scer\GAL4^da.G32

(Lu et al., 2022)

visible | adult stage, with Scer\GAL4^GMR.PU

(Ansar et al., 2018)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Ansar et al., 2018)

interommatidial bristle | pupal stage, with Scer\GAL4^GMR.PU

(Ansar et al., 2018)

pigment cell | pupal stage, with Scer\GAL4^GMR.PU

(Ansar et al., 2018)

Detailed Description

Statement

Reference

The expression of sif^HMJ23517 under the control of Scer\GAL4^da.G32 results in decreased climbing activity and heat-induced paralysis. Expression under the control of Scer\GAL4^elav.PU also results in decreased climbing activity and heat-induced paralysis.

(Lu et al., 2022)

Expressing sif^HMJ23517 under the control of Scer\GAL4^GMR.PU leads to eye defects: the pupal eye shows some aberrant interommatidial pigment cells and some aberrant or missing eye bristle cells; adults show a rough eye phenotype and a decrease in electroretinogram amplitude, as compared to controls.

(Ansar et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions