FlyBase Allele Report: Dmel\CSN5[HMJ30047]

General Information

Symbol

Dmel\CSN5^HMJ30047

Species

D. melanogaster

Name

FlyBase ID

FBal0315872

Feature type

allele

Associated gene

Dmel\CSN5

Associated Insertion(s)

Carried in Construct

P{TRiP.HMJ30047}

Also Known As

CSN5 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMJ30047}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMJ30047

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity | male, with Scer\GAL4^bam.PU

(Grewal et al., 2021)

decreased size | male, with Scer\GAL4^bam.PU

(Grewal et al., 2021)

male sterile, with Scer\GAL4^bam.PU

(Grewal et al., 2021)

Phenotype Manifest In

karyosome, with Scer\GAL4^{VP16.nanos.UTR}

(Barbosa et al., 2021)

seminal vesicle, with Scer\GAL4^bam.PU

(Grewal et al., 2021)

spermatozoon | absent, with Scer\GAL4^bam.PU

(Grewal et al., 2021)

synaptonemal complex | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Barbosa et al., 2021)

Detailed Description

Statement

Reference

The expression of CSN5^HMJ30047 under the control of Scer\GAL4^VP16.nos.UTR induces a distorted karyosome in the oocyte. In addition, the synaptonemal complex is spotty/fragmented.

(Barbosa et al., 2021)

Males expressing CSN5^HMJ30047 under the control of Scer\GAL4^bam.PU have visible spermatids but smaller seminal vesicles devoid of sperm.

(Grewal et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

CSN5^HMJ30047, Scer\GAL4^ppl.PP, mdy^UAS.cHa has embryonic/larval fat body | third instar larval stage phenotype

(Zhao et al., 2022)

CSN5^HMJ30047, Scer\GAL4^ppl.PP, mdy^UAS.cHa has lipid droplet | third instar larval stage phenotype

(Zhao et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

The double expression of mdy^UAS.cHa with CSN5^HMJ30047 under the control of Scer\GAL4^ppl.PP leads to enlarged lipid droplets in the third instar larval fat body.

(Zhao et al., 2022)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

62970