FB2026_02 , released June 18, 2026
Allele: Dmel\ago12A021
Open Close
General Information
Symbol
Dmel\ago12A021
Species
D. melanogaster
Name
FlyBase ID
FBal0316332
Feature type
allele
Associated gene
Dmel\ago
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bivik et al., 2015)
Progenitor genotype
Cytology
Description

Amino acid replacement: G1091D.

(Bivik et al., 2015)

Nucleotide substitution: C3272T.

(Bivik et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:4,248,397..4,248,397 [-]
Nucleotide change:

G4248397A

Reported nucleotide change:

C3272T

Amino acid change:

G1091D | ago-PA; G1091D | ago-PB; G1091D | ago-PC

Reported amino acid change:

G1091D

Comment:

The reported nucleotide change is relative to the non-coding strand.

(Bivik et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show loss of expression of P{FMRFa-EGFP.Tv}, a marker for the six Ap4 neurons in the developing ventral nerve cord, and either loss of or extra expression of eya, which identifies the four Ap cluster neurons.

      (Bivik et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      ago1

      (Bivik et al., 2015)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ago12A021
      (Bivik et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)