FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\egrecto-60.UAS.Tag:HA,Tag:FLAG
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General Information
Symbol
Dmel\egrecto-60.UAS.Tag:HA,Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0316403
Feature type
allele
Associated gene
Dmel\egr
Associated Insertion(s)
Carried in Construct
P{UAS-egr.ecto.60}
Also Known As
UAS-ecto-egr-60
Key Links
Transgenic product class
inframe_deletion
(Narasimamurthy et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Narasimamurthy et al., 2009)
Mutagen
in vitro construct
(Narasimamurthy et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-egr.ecto.60}
Cytology
Description

UAS regulates expression of the entire extracellular domain of egr (amino acids 1-59 are absent) tagged at the N-terminus with a hemagglutinin signal peptide and Tag:FLAG.

(Narasimamurthy et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
egr
Tagged with
Tag:FLAG
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of egrecto-60.UAS.Tag:HA,Tag:FLAG under the control of Scer\GAL4rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) leads to occasional ectopic wings compared to controls.

      (Worley et al., 2018)

      Scer\GAL4GMR.PU-mediated expression results in a small-eye phenotype.

      (Andersen et al., 2015)

      Scer\GAL4GMR.PU-mediated expression induces a severe 'apoptotic eye' phenotype.

      (Narasimamurthy et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The Scer\GAL4GMR.PU egrecto-60.Scer\UAS.T:Ivir\HA1,T:Zzzz\FLAG small eye phenotype is partially rescued through co-expression of pucScer\UAS.cMa, resulting in a 'hanging eye' phenotype.

      (Andersen et al., 2015)

      Scer\GAL4GMR.PU-mediated co-expression of egrecto-60.Scer\UAS.T:Ivir\HA1,T:Zzzz\FLAG and pucScer\UAS.cMa results in a novel 'hanging-eye' phenotype. When co-expressed in wing disc clones, this combination induces apoptosis in neighbouring cells.

      (Narasimamurthy et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      egrecto-60.Scer\UAS.T:Ivir\HA1,T:Zzzz\FLAG
      egrecto-60.UAS.Tag:HA,Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (4)