FlyBase Allele Report: Dmel\upd1[RNAi.UAS.cUa]

General Information

Symbol

Dmel\upd1^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0316451

Feature type

allele

Associated gene

Dmel\upd1

Associated Insertion(s)

Carried in Construct

P{UAS-upd1.RNAi.U}

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-upd1.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi construct targeting upd1.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

upd1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Ras85D^V12.UAS, l(2)gl^unspecified

(Wu et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified, upd1^RNAi.UAS.cUa has neoplasia | somatic clone | cell autonomous phenotype, suppressible by upd2^Δ3-62

(Wu et al., 2010)

Suppressor of

Statement

Reference

upd1^RNAi.UAS.cUa, Scer\GAL4^Act.PU is a suppressor | partially of neoplasia | somatic clone | cell autonomous phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified

(Wu et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified, upd1^RNAi.UAS.cUa has eye disc | somatic clone | cell autonomous phenotype, suppressible by upd2^Δ3-62

(Wu et al., 2010)

Suppressor of

Statement

Reference

upd1^RNAi.UAS.cUa, Scer\GAL4^Act.PU is a suppressor | partially of eye disc | somatic clone | cell autonomous phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, l(2)gl^unspecified

(Wu et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of upd1^{dsRNA.Scer\UAS.cUa} partially suppresses the overgrowth and invasion of the nerve cord seen in l(2)gl^unspecified mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU. The phenotype is further suppressed when the clones are generated in a upd2^Δ3-62 mutant background.

(Wu et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

upd1^RNAi.UAS.cUa

upd1^{dsRNA.Scer\UAS.cUa}

upd1^{dsRNA.UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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