FlyBase Allele Report: Dmel\dap[HMS05362]

General Information

Symbol

Dmel\dap^HMS05362

Species

D. melanogaster

Name

FlyBase ID

FBal0316985

Feature type

allele

Associated gene

Dmel\dap

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS05362}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMS05362}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS05362

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates carcinoma

modeled by Ras85D^V12.UAS

(Ito and Igaki, 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased occurrence of cell division | larval stage, with Scer\GAL4^wor.PA

(Sood et al., 2022)

Phenotype Manifest In

larval central brain, with Scer\GAL4^wor.PA

(Sood et al., 2022)

larval neuroblast, with Scer\GAL4^wor.PA

(Sood et al., 2022)

Detailed Description

Statement

Reference

The expression of dap^HMS05362 under the control of Scer\GAL4^wor.PA or Scer\GAL4^GMR25B11 results in larval central brain neuroblasts ectopically proliferating (i.e. increased numbers in S-phase), compared to controls.

(Sood et al., 2022)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

dap^HMS05362/Scer\GAL4^ap.PU is an enhancer of increased size | larval stage phenotype of Scer\GAL4^ap.PU, yki^UAS.cHa

(Sew et al., 2025)

dap^HMS05362, Scer\GAL4^wor.PA is an enhancer of increased occurrence of cell division | larval stage phenotype of N^HMS00001, Scer\GAL4^wor.PA

(Sood et al., 2022)

dap^HMS05362, Scer\GAL4^Act.PU is an enhancer of neoplasia | larval stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

dap^HMS05362/Scer\GAL4^ap.PU is an enhancer of wing disc | larval stage phenotype of Scer\GAL4^ap.PU, yki^UAS.cHa

(Sew et al., 2025)

dap^HMS05362/Scer\GAL4^ap.PU is an enhancer of site of double-strand break | increased number phenotype of Scer\GAL4^ap.PU, yki^UAS.cHa

(Sew et al., 2025)

dap^HMS05362, Scer\GAL4^wor.PA is an enhancer of larval neuroblast phenotype of N^HMS00001, Scer\GAL4^wor.PA

(Sood et al., 2022)

dap^HMS05362, Scer\GAL4^wor.PA is an enhancer of larval central brain phenotype of N^HMS00001, Scer\GAL4^wor.PA

(Sood et al., 2022)

dap^HMS05362, Scer\GAL4^Act.PU is an enhancer of eye-antennal disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Ito and Igaki, 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

64026

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05362}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dap^HMS05362

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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