FB2026_02 , released June 18, 2026
Allele: Dmel\mod(mdg4)m9
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General Information
Symbol
Dmel\mod(mdg4)m9
Species
D. melanogaster
Name
FlyBase ID
FBal0318604
Feature type
allele
Associated gene
Dmel\mod(mdg4)
Associated Insertion(s)
P{5'.FRT(w3').5'}mod(mdg4)m9
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Savitsky et al., 2016)
Progenitor genotype
P{RS5}mod(mdg4)5-HA-1224
(Savitsky et al., 2016)
P{RS3}mod(mdg4)CB-6686-3
(Savitsky et al., 2016)
Associated Insertion(s)
P{5'.FRT(w3').5'}mod(mdg4)m9
Cytology
Description

Deletion of part of mod(mdg4), removing the transcription start site, four exons which are common to all isoforms and eight other downstream exons. Generated by FLP-mediated recombination between FRT sites present in the P{RS5}mod(mdg4)5-HA-1224 and P{RS3}mod(mdg4)CB-6686-3 insertions. A residual element consisting of the 5' P-element end and the 3' part of the w gene from the P{RS5} element and the 5' P-element end from the P{RS3} element are present.

(Savitsky et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:21,365,352..21,377,367 [-]
Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them.

(Savitsky et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mod(mdg4)m9/mod(mdg4)neo129 have 75% early pupal (P1-4) lethality, and 25% late pupa to pharate adult lethality (stage 12-15) and pharate adults show homeotic transformations (abdominal segments A6-8): in males s6 (sternite of the sixth segment) has 3-7 (average 5) bristles, t7 (tergite of the seventh segment) is enlarged and bears several bristles; in females s7 bears 9-11 bristles and occasionally 3 large bristles instead of 2, bristles on s7 occasionally lose orientation, and t8 occasionally bears 1-2 bristles.

      mod(mdg4)m9/mod(mdg4)GS23019 have pharate adult lethality and homeotic transformations (A6-8): in males s6 has 3-5 bristles, t7 is enlarged and bears several bristles; in females s7 bears 7-14 (average 9.5) bristles and often 3 large bristles instead of 2, and t8 occasionally bears a couple of small bristles.

      (Savitsky et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      CTCFy+1 mod(mdg4)neo129 / CTCFEY15833 mod(mdg4)m9 show early pupal lethality (stage P1-4).

      Though Cp190P1/Cp1903 or mod(mdg4)m9/mod(mdg4)GS23019 flies die as pharate adults with fully formed cuticles, Cp190P1 mod(mdg4)m9/Cp1903 mod(mdg4)GS23019 double mutant flies die as pupae (P5-7).

      CTCFy+1 mod(mdg4)GS23019 / CTCFEY15833 mod(mdg4)m9 show early pupal lethality (stage P1-4), with rare escapers that die at pharate adult stage and show strong homeotic transformations (A6-8): in males genitalia is rotated by 180[o], s6 has 4-11 (average 9) bristles, display a small cuticle structure with 1-2 bristles interpreted as s7, t7 is well developed, and t8 is well separated from t9 and bears rows of large bristles; in females phenotypes are as in CTCFy+1/CTCFEY15833 but t8 always has rows of large bristles.

      (Savitsky et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mod(mdg4)m9
      (Savitsky et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)