FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ppkΔ16
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General Information
Symbol
Dmel\ppkΔ16
Species
D. melanogaster
Name
FlyBase ID
FBal0318624
Feature type
allele
Associated gene
Dmel\ppk
Associated Insertion(s)
Mi{?ET1}ppkΔ16
Carried in Construct
Also Known As
ppk1Δ16
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Gorczyca et al., 2014)
Mutagen
minos activity
(Gorczyca et al., 2014)
Progenitor genotype
Mi{ET1}MB10310
(Gorczyca et al., 2014)
Associated Insertion(s)
Mi{?ET1}ppkΔ16
Cytology
Description

The entire ppk open reading frame is deleted. Generated by excision of the Mi{ET1}MB10310 insertion; a portion of the original Mi{ET1} element remains. PCR analysis indicates that the neighbouring spel1 and elB genes are intact.

(Gorczyca et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ppkΔ16/ppkΔ16 (but not ppkΔ16/+) third instar larvae have significantly reduced turning frequency (locomotor defects) and show normal thermal (response to heat probe) nociception.

      (Gorczyca et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      NOT suppressed by
      NOT Enhancer of
      NOT Suppressor of
      Statement
      Reference

      ppkΔ16 is a non-suppressor of abnormal pain response | larval stage phenotype of ppk261

      (Guo et al., 2025)

      ppkΔ16/ppkΔ16 is a non-suppressor of abnormal locomotor behavior | third instar larval stage phenotype of ppk26Δ29

      (Gorczyca et al., 2014)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ppk26Δ29/ppk26Δ29;ppkΔ16/ppkΔ16 double mutant third instar larvae have similar locomotor turning frequency defects as either single mutant.

      (Gorczyca et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Df(2L)ppk1rv16
      (Gorczyca et al., 2014)
      ppk1KO
      (Guo et al., 2025)
      ppk1Δ16
      (Jang et al., 2022, Li et al., 2016)
      ppk1Δ16
      (Gorczyca et al., 2014)
      ppkΔ16
      (Gong et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)