FlyBase Allele Report: Dmel\Lmx1a[UAS.cWa]

General Information

Symbol

Dmel\Lmx1a^UAS.cWa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Wang

FlyBase ID

FBal0318731

Feature type

allele

Associated gene

Dmel\Lmx1a

Associated Insertion(s)

Carried in Construct

P{UAS-Lmx1a.W}

Key Links

Transgenic product class

wild_type

(Wang et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Wang et al., 2016)

Mutagen

in vitro construct

(Wang et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-Lmx1a.W}

Cytology

Description

UAS regulatory sequences drive expression of Lmx1a.

(Wang et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Lmx1a

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ey.PU

(Wang et al., 2016)

visible, with Scer\GAL4^GMR.PU

(Wang et al., 2016)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PU

(Wang et al., 2016)

eye, with Scer\GAL4^GMR.PU

(Wang et al., 2016)

Detailed Description

Statement

Reference

Expression of Lmx1a^Scer\UAS.cWa when driven by Scer\GAL4^ey.PU nearly ablates fly eyes, and when driven by Scer\GAL4^GMR.PU results in small defective eyes.

(Wang et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by Chi^GL00360, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by Chi^UAS.cWa, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by Chi^{ΔLID.UAS.cWa}, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by Chi^ΔDD.UAS.cWa, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by eya^UAS.cBa, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by eya^UAS.cBb, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by eya^UAS.cBa, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by eya^UAS.cBb, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Chi^GL00360, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Chi^UAS.cWa, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Chi^{ΔLID.UAS.cWa}, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Lmx1a^UAS.cWa, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Chi^ΔDD.UAS.cWa, Scer\GAL4^GMR.PU

(Wang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Chi^GL00360, Chi^Scer\UAS.cWa, Chi^{ΔLID.Scer\UAS.cWa}, Chi^{ΔDD.Scer\UAS.cWa}, eya^Scer\UAS.cBa or eya^Scer\UAS.cBb partially suppresses the eye defects seen in flies with Lmx1a^Scer\UAS.cWa driven by Scer\GAL4^GMR.PU.

(Wang et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Lmx1a^UAS.cWa is partially rescued by Scer\GAL4^GMR.PU/Lmx1a^RNAi.UAS.cWa

(Wang et al., 2016)

Lmx1a^UAS.cWa is partially rescued by Lmx1a^ΔLIM.UAS/Scer\GAL4^GMR.PU

(Wang et al., 2016)

Lmx1a^UAS.cWa is partially rescued by Lmx1a^ΔHD.UAS/Scer\GAL4^GMR.PU

(Wang et al., 2016)

Comments

Co-expression of Lmx1a^{dsRNA.Scer\UAS.cWa}, Lmx1a^{ΔLIM.Scer\UAS} or Lmx1a^{ΔHD.Scer\UAS} partially suppresses eye defects seen in flies with Lmx1a^Scer\UAS.cWa driven by Scer\GAL4^GMR.PU.

(Wang et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Lmx1a^Scer\UAS.cWa

Lmx1a^UAS.cWa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Wang

Secondary FlyBase IDs

References (1)

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