FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eIF4EHPΔ
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General Information
Symbol
Dmel\eIF4EHPΔ
Species
D. melanogaster
Name
FlyBase ID
FBal0318826
Feature type
allele
Associated gene
Dmel\eIF4EHP
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Valzania et al., 2016)
Progenitor genotype
PBac{RB}eIF4EHPe03164
(Valzania et al., 2016)
PBac{RB}eIF4EHPe01165
(Valzania et al., 2016)
Caused by aberration
Df(3R)eIF4EHPΔ
Cytology
Description

Deletion of genomic sequence that encompasses all of exon 2 and most of exon 3 of 4EHP. The deletion also removes all of the nested Syx1A gene.

(Valzania et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:24,064,246..24,107,432 [-]
Comment:

Inferred boundaries of 43.1 kb deletion that removes all of exon 2 and most of exon 3 of eIF4EHP, created using PBac{RB}eIF4EHPe01165 and PBac{RB}eIF4EHPe03164. The deletion also removes the nested Syx1A gene.

(Valzania et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      4EHPΔ/4EHPΔ (using Df(3R)4EHPΔ along with a transgene to restore wild type Syx1A function) larvae exhibit extreme developmental delay: 5 days after egg deposition, mutant larvae are significantly smaller than heterozygous siblings and show mouth hook morphology characteristic of second instar larvae - without increasing in size, they die 2-3 days later.

      (Valzania et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      4EHPΔ
      (Valzania et al., 2016)
      eIF4EHPΔ
      Name Synonyms
      Secondary FlyBase IDs
        References (1)