FlyBase Allele Report: Dmel\path[Δ]

General Information

Symbol

Dmel\path^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0319205

Feature type

allele

Associated gene

Dmel\path

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Lin et al., 2015)

Progenitor genotype

Cytology

Description

Deletion that removes the entire short path isoform, leaving coding sequences for the first 16 amino acids of the long path isoform but no other portion of the protein.

(Lin et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage

(Lin et al., 2015)

abnormal neuroanatomy | larval stage (with Df(3L)BSC773)

(Lin et al., 2015)

viable

(Lin et al., 2015)

Phenotype Manifest In

dendrite | larval stage

(Lin et al., 2015)

dendrite | larval stage (with Df(3L)BSC773)

(Lin et al., 2015)

larval multidendritic class IV neuron | larval stage

(Lin et al., 2015)

larval multidendritic class IV neuron | larval stage (with Df(3L)BSC773)

(Lin et al., 2015)

Detailed Description

Statement

Reference

path^Δ/path^Δ mutants do not show significant defects in larval growth. path^Δ/path^Δ or path^Δ/Df(3L)BSC773 larvae show defects in C4da dendrite growth, with path^Δ/Df(3L)BSC773 mutants showing significant reductions in dendrite length compared to wild type. path^GFP/path^dg50 or path^GFP/path^Δ larvae show normal dendrite growth in C4da neurons.

(Lin et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

path^Δ

(Lin et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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