FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rab3-GEFMA18
Open Close
General Information
Symbol
Dmel\Rab3-GEFMA18
Species
D. melanogaster
Name
FlyBase ID
FBal0319215
Feature type
allele
Associated gene
Dmel\Rab3-GEF
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bae et al., 2016)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q1682term.

(Bae et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:15,102,873..15,102,873 [+]
Nucleotide change:

C15102873T

Amino acid change:

Q1654term | Rab3-GEF-PC; Q1700term | Rab3-GEF-PD; Q1694term | Rab3-GEF-PE; Q1654term | Rab3-GEF-PF; Q1654term | Rab3-GEF-PG; Q1665term | Rab3-GEF-PH; Q1665term | Rab3-GEF-PI; Q1682term | Rab3-GEF-PJ; Q1714term | Rab3-GEF-PK; Q1714term | Rab3-GEF-PL

Reported amino acid change:

Q1682term

Comment:

Amino acid substitution reported relative to 2115 aa isoform. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bae et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At the neuromuscular junction of Rab3-GEFMA18/Df(1)ED7289 third instar larvae, brp aggregates at only a subset of active zones in puncta that are significantly larger than normal (results in the majority of GluRIIC clusters being unapposed to a brp-positive active zone).

      (Bae et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Rab3Q80L.Scer\UAS driven by Scer\GAL4VGlut.PD does not suppress active zone phenotypes seen at the NMJ of Rab3-GEFMA18/Df(1)ED7289 third instar larvae.

      (Bae et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rab3-GEFMA18
      rab3-GEFMA18
      (Bae et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)