FB2026_02 , released June 18, 2026
Allele: Dmel\Schip149
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General Information
Symbol
Dmel\Schip149
Species
D. melanogaster
Name
FlyBase ID
FBal0319325
Feature type
allele
Associated gene
Dmel\Schip1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Chung et al., 2016)
    Mutagen
    Progenitor genotype
    P{GSV6}Schip1GS12074
    (Chung et al., 2016)
    Cytology
    Description

    977bp deletion within Schip1, removing 265 amino acid residues (227 to 491). (Revision of data reported in FBrf0231239).

    (Chung and Choi, 2016.6.24)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    2L:10,328,850..10,329,826 [-]
    Comment:

    A 977 bp deletion (including 794 bp of coding sequence) resulting from the imprecise excision of P{GSV6}Schip1GS12074, which removes amino acids 227 to 491.

    (Chung et al., 2016)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Schip149/Schip149 or Schip149/Df(2L)Exel7046 mutants are lethal during embryogenesis or an early larval stage. Schip149/Schip149 mutant clones in the eye result in enlarged eyes with irregular bulging at the surface; in mid-pupal eyes, mutant clones show an increase in the number of interommatidial cells. Schip149/Schip149 mutant clones are much larger than control clones (mutant cells have strong growth advantages). Schip149/Schip149 eye disc clones show mitotic activity posterior to the second mitotic wave, with mutant cells failing to exit the cell cycle and continuing to proliferate.

        (Chung et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Schip149
        (Chung and Choi, 2016.6.24, Chung et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)