FlyBase Allele Report: Dmel\Girdin[101]

General Information

Symbol

Dmel\Girdin¹⁰¹

Species

D. melanogaster

Name

FlyBase ID

FBal0319530

Feature type

allele

Associated gene

Dmel\Girdin

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q505term.

(Ha et al., 2015)

Nucleotide substitution: C2161T.

(Ha et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:3,181,513..3,181,513 [+]

Nucleotide change:

C3181513T

Reported nucleotide change:

C2161T

Amino acid change:

Reported amino acid change:

Q505term

(Ha et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | P-stage

(Ha et al., 2015)

abnormal neurophysiology | adult stage

(Ha et al., 2015)

uncoordinated | adult stage

(Ha et al., 2015)

visible

(Ha et al., 2015)

Phenotype Manifest In

dendrite | P-stage

(Ha et al., 2015)

mechanosensory neuron | adult stage

(Ha et al., 2015)

mechanosensory neuron | P-stage

(Ha et al., 2015)

mechanosensory sensory organ | P-stage

(Ha et al., 2015)

wing blade

(Ha et al., 2015)

Detailed Description

Statement

Reference

Girdin¹⁰¹ homozygotes show a severely uncoordinated phenotype (unable to stand on legs, legs are crossed, wings are held straight up).

Recordings from bristles in Girdin¹⁰¹ mutants show they do not have mechanoreceptor currents (MRC) but are able to maintain normal transepithelial potentials (TEP). Mechanosensory neurons of Girdin¹⁰¹ late pupae show several phenotypes: 60% of the thoracic mechanosensory organs are missing their neurons, and most of the remaining 40% with sensory neurons do not have dendrites (with the remainder having abnormally short dendrites that fail to innervate the bristle base); cell bodies of those neurons lacking dendrites often cluster together. Girdin¹⁰¹ pupae also show defects in the dendritic sheath, which does not contain a sensory cilium within the tubular body.

At 30-50hr APF, all sensory neurons have an axon and a dendrite in Girdin¹⁰¹ pupae; at 60-70hr APF, many dendrites begin to degenerate and cell bodies form clusters.

(Ha et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Girdin¹⁰¹ is rescued by Girdin^GFP

(Ha et al., 2015)

Comments

Girdin^T:Avic\GFP rescues behavioral phenotypes and sensory neuron dendrite degeneration, and generates viable Girdin¹⁰¹ flies.

(Ha et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Girdin¹⁰¹

girdin¹⁰¹

(Ha et al., 2015)

mecA¹⁰¹

(Ha et al., 2015)

pmm101

(Ha et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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