FB2026_02 , released June 18, 2026
Allele: Dmel\Trap1D6
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General Information
Symbol
Dmel\Trap1D6
Species
D. melanogaster
Name
FlyBase ID
FBal0319561
Feature type
allele
Associated gene
Dmel\Trap1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Kim et al., 2016)
Mutagen
Delta2-3 transposase
(Kim et al., 2016)
Progenitor genotype
P{EPgy2}Trap1EY21851
(Kim et al., 2016)
Cytology
Description

2.9kb deletion (coordinates 2R:6632775..6635658 , release 6 genome) that removes most of the Trap1 open reading frame (amino acids 86-691 are deleted). Generated by imprecise excision of P{EPgy2}Trap1EY21851.

(Kim et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:6,632,775..6,635,658 [-]
Comment:

Reported as a deletion of the region from 2R:6632775..6635658 in release 6 genome coordinates.

(Kim et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Kim et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Trap1D6/Trap1D6 mutants show normal mitochondrial function and morphology in the indirect flight muscle compared to revertant controls. When placed on medium containing paraquat or rotenone, Trap1D6/Trap1D6 male flies show significantly increased survival compared to revertant and wild type flies.

      (Kim et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Trap1D6/Trap1D6 is a suppressor of abnormal oxidative stress response | adult stage | chemical conditional phenotype of Pink1B9

      (Kim et al., 2016)

      Trap1D6/Trap1D6 is a suppressor | partially of visible phenotype of Pink1B9

      (Kim et al., 2016)

      Trap1D6/Trap1D6 is a suppressor of increased cell death | adult stage phenotype of Pink1B9

      (Kim et al., 2016)

      Trap1D6/Trap1D6 is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Pink1B9

      (Kim et al., 2016)

      Trap1D6/Trap1D6 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Pink1B9

      (Kim et al., 2016)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Trap1D6/Trap1D6 is a suppressor of dopaminergic PPM2 neuron | adult stage phenotype of Pink1B9

      (Kim et al., 2016)

      Trap1D6/Trap1D6 is a suppressor | partially of mesonotum phenotype of Pink1B9

      (Kim et al., 2016)

      Trap1D6/Trap1D6 is a suppressor | partially of wing phenotype of Pink1B9

      (Kim et al., 2016)

      Trap1D6/Trap1D6 is a suppressor of indirect flight muscle cell phenotype of Pink1B9

      (Kim et al., 2016)

      Trap1D6/Trap1D6 is a suppressor | partially of mitochondrion | adult stage phenotype of Pink1B9

      (Kim et al., 2016)

      Trap1D6/Trap1D6 is a suppressor of dopaminergic PPL1 neuron | adult stage phenotype of Pink1B9

      (Kim et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Presence of Trap1D6/Trap1D6 significantly suppresses decreased survival in response to rotenone, crushed thorax and downturned wing phenotypes, cell death and disrupted mitochondrial function, and locomotor defects seen in Pink1B9/Pink1B9 flies. Trap1D6/Trap1D6 or Trap1EY21851/Trap1EY21851 significantly suppress dopamine neuron (DL1 and DM) loss in Pink1B9/Pink1B9 30 day old flies.

      (Kim et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TRAP1D6
      (Kim et al., 2016)
      Trap1D6
      Name Synonyms
      Secondary FlyBase IDs
        References (1)