FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ken141
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General Information
Symbol
Dmel\ken141
Species
D. melanogaster
Name
FlyBase ID
FBal0319631
Feature type
allele
Associated gene
Dmel\ken
Associated Insertion(s)
P{GAL4}ken141
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GAL4}ken141
    Cytology
    Description

    Insertion within ken, 59bp downstream of the transcription start site.

    (Allen et al., 2007)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GAL4}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Flies homozygous for ken141 undergo embryonic development but fail to hatch, but no defects were observed in the number of neurons or their projections.

        ken141/ken1 transheterozygotes display the same adult phenotypes (abnormal, often missing, genitalia; unpigmented aristae; wings held out away from the body) characteristic or viable ken mutants. No obvious morphological defects are seen in the giant fiber neurons.

        Homozygous ken1 mutant adults as well as ken1/Df(2R)or-BR11 hemizygotes and ken1/ken141 transheterozygotes show defective light-off escape behavior, phototaxis and general locomotor activity compared to wild-type controls, with the hemizygotes showing the most severe phenotype in all assays.

        Both adult ken1 homozygotes and ken141/ken1 transheterozygotes show defects in the electrophysiology of the giant fibre system: they display longer response latencies and a lower percentage following to 10 stimuli at 250Hz in tergo trochantal muscles compared to wild-type controls. When stimulated directly, the muscles of ken1 mutants respond with the correct short latency characteristic for normal neuromuscular junctions.

        (Allen et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        ken1

        (Allen et al., 2007)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        ken141
        Name Synonyms
        Secondary FlyBase IDs
          References (1)