FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\His3HisGU.K115R.K122R
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General Information
Symbol
Dmel\His3HisGU.K115R.K122R
Species
D. melanogaster
Name
FlyBase ID
FBal0319715
Feature type
allele
Associated gene
His3
Associated Insertion(s)
Carried in Construct
PBac{3xHisGU.H3K115R.H3K122R}
Key Links
Transgenic product class
missense_variant
(Graves et al., 2016)
polypeptide_post_translational_processing_variant
(Graves et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Graves et al., 2016)
polypeptide_post_translational_processing_variant
(Graves et al., 2016)
Mutagen
in vitro construct
(Graves et al., 2016)
Progenitor genotype
Carried in construct
PBac{3xHisGU.H3K115R.H3K122R}
Cytology
Description

Mutated His3 gene (amino acid replacements K115R and K122R, each to prevent acetylation) in the context of a histone gene repeat unit.

(Graves et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
His3
Encoded product / tool
His3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      His3HisGU.K115R.K122R partially rescues Df(2L)HisC

      (Graves et al., 2016)
      Comments

      12 copies of a histone repeat unit containing the His3HisGU.K115R.K122R mutation (flies contain 4 copies of PBac{3xHisGU.H3K115R.H3K122R}) fails to rescue the embryonic lethality of Df(2L)HisC homozygotes.

      12 copies of a histone repeat unit containing the His3HisGU.K115R.K122R mutation (flies contain 4 copies of PBac{3xHisGU.H3K115R.H3K122R}) only partially rescue the severe growth defect seen in homozygous Df(2L)HisC clones in the wing disc; the rescued clones are significantly smaller than their twin spots (which are heterozygous for Df(2L)HisC).

      (Graves et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      His3HisGU.K115R.K122R
      Name Synonyms
      Secondary FlyBase IDs
        References (1)