FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\stwl262708
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General Information
Symbol
Dmel\stwl262708
Species
D. melanogaster
Name
FlyBase ID
FBal0319741
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

P-element insertion site between nucleotides 280 and 281 in the stwl exon 1, yielding a premature stop codon at 11 nucleotides downstream from the 5' end of the P-element. The predicted size of the mutant protein is 43 amino acid residues, while wild-type stwl protein encodes 1037 amino acid residues - almost all of the functional domains should be lost in the mutant protein.

Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The ovarioles of stwl262708/stwl262708 mutant adult females contain some abnormally developing egg chambers, and some ovarioles are devoid of egg chambers; spectrosomes are absent from mutant germaria, and branched fusomes are largely absent from the ovary, although an excess of fusomes with a low level of branching remain; and there is a dramatic reduction in stem cell number in mutant germaria over the first week of adulthood, and abnormal expansion and elongation of the germaria. A number of germaria in stwl262708/stwl262708 mutant pupae show defects including reduced germline stem cell number, lack of germline, or discontinuous production of cysts.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
fs(3)262708
stwl262708
Name Synonyms
Secondary FlyBase IDs
    References (1)