FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dlg1intol
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General Information
Symbol
Dmel\dlg1intol
Species
D. melanogaster
Name
FlyBase ID
FBal0319742
Feature type
allele
Associated gene
Dmel\dlg1
Associated Insertion(s)
P{GawB}dlg1intol
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Maiya et al., 2012)
Progenitor genotype
Associated Insertion(s)
P{GawB}dlg1intol
Cytology
Description

Insertion within an intron of dlg1.

(Maiya et al., 2012)
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      dlg1intol/dlg1intol mutants, but not dlg1intol/+, exhibit a drastic reduction of acquired tolerance to ethanol vapor-induced sedation, in both acute and chronic tolerance assays; and a small but significant decrease in ethanol sensitivity as compared to controls. Ethanol absorption and metabolism, and synaptic transmission appear to be unaffected in dlg1intol/dlg1intol mutants.

      (Maiya et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      dlg1intol is partially rescued by Scer\GAL4c747/dlg1S97N.UAS.EGFP

      (Maiya et al., 2012)
      Not rescued by

      dlg1intol is not rescued by Scer\GAL4dlg1-intol/dlg1UAS.EGFP

      (Maiya et al., 2012)

      dlg1intol is not rescued by Scer\GAL4c747/dlg1UAS.EGFP

      (Maiya et al., 2012)

      dlg1intol is not rescued by Scer\GAL4dlg1-intol/dlg1S97N.UAS.EGFP

      (Maiya et al., 2012)
      Comments

      Expression of dlg1Scer\UAS.T:Avic\GFP or dlg1S97N.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4dlg1-intol does not rescue the defective ethanol tolerance of dlg1intol/dlg1intol mutants.

      Expression of dlg1S97N.Scer\UAS.T:Avic\GFP-EGFP, but not dlg1Scer\UAS.T:Avic\GFP, under the control of Scer\GAL4c747 partially rescues the defective ethanol tolerance of dlg1intol/dlg1intol mutants.

      (Maiya et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      dlg1-intol
      (Maiya et al., 2012)
      dlg1intol
      Name Synonyms
      intolerant
      (Maiya et al., 2012)
      Secondary FlyBase IDs
        References (1)