FB2026_02 , released June 18, 2026
Allele: Dmel\nemy26.2
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General Information
Symbol
Dmel\nemy26.2
Species
D. melanogaster
Name
FlyBase ID
FBal0319764
Feature type
allele
Associated gene
Dmel\nemy
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Knight et al., 2015)
Mutagen
P-element activity
(Knight et al., 2015)
Progenitor genotype
P{EP}nemyGE16037
(Knight et al., 2015)
Cytology
Description

Imprecise excision of the progenitor insertion resulting in deletion of all/most of the 5' non-coding (UTR) exon of transcripts nemy-RB, -RC, RE and -RG, but not -RA or -RF. Correspondingly, expression of nemy-RA is unaffected, while expression of the remaining transcripts is significantly reduced.

(Knight et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      nemy26.2/nemy26.2 third instar larvae show a small significant increase in the amplitude of miniature excitatory junction potentials (mEJPs), but no difference in mEJP frequency, at the neuromuscular junction (NMJ) compared to controls. nemy26.2/nemy26.2 larvae show similar amplitude of evoked EJPs and a significant decrease in quantal content compared to controls. nemy26.2/nemy26.2 larvae have a significant decrease in bouton number at the NMJ compared to controls. Controls show mild paired pulse potentiation at short inster-stimulus intervals; this paired pulse potentiation is enhanced in nemy26.2/nemy26.2 larvae.

      (Knight et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      nemy26.2
      (Knight et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)