FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SdcΔC2.UAS.Tag:MYC
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General Information
Symbol
Dmel\SdcΔC2.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0319782
Feature type
allele
Associated gene
Dmel\Sdc
Associated Insertion(s)
Carried in Construct
P{UAS-Sdc.ΔC2}
Key Links
Transgenic product class
inframe_deletion
(Nguyen et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Nguyen et al., 2016)
Mutagen
in vitro construct
(Nguyen et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-Sdc.ΔC2}
Cytology
Description

UAS regulatory sequences drive expression of Sdc lacking the C2 domain. The protein is tagged in the extracellular domain with a 5x Tag:MYC tag.

(Nguyen et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sdc
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of SdcΔC2.Scer\UAS.T:Hsap\MYC driven post-synaptically by Scer\GAL4how-24B does not significantly change the number of boutons per neuromuscular junction, compared to controls.

      (Nguyen et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Sdc10608/Df(2R)48 third instar larvae (in which Sara function has been rescued by SaraUbi.PJ) have a decrease in the number of boutons per neuromuscular junction, compared to controls; this phenotype is not rescued by expression of SdcΔC2.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4how-24B.

      (Nguyen et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      SdcΔC2.UAS.Tag:MYC/Scer\GAL4how-24B fails to rescue Sdc10608/Df(2R)48

      (Nguyen et al., 2016)
      Comments

      Sdc10608/Df(2R)48 third instar larvae (in which Sara function has been rescued by SaraUbi.PJ) have a decrease in the number of boutons per neuromuscular junction, compared to controls; this phenotype is not rescued by expression of SdcΔC2.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4how-24B.

      (Nguyen et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SdcΔC2.Scer\UAS.T:Hsap\MYC
      SdcΔC2.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)