FB2026_02 , released June 18, 2026
Allele: Hsap\CACNA1AUAS.αACT.Q11
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General Information
Symbol
Hsap\CACNA1AUAS.αACT.Q11
Species
H. sapiens
Name
FlyBase ID
FBal0319787
Feature type
allele
Associated gene
Hsap\CACNA1A
Associated Insertion(s)
Carried in Construct
P{UAS-αACT.Q11}
Key Links
Transgenic product class
wild_type
(Tsou et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tsou et al., 2015)
Mutagen
in vitro construct
(Tsou et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-αACT.Q11}
Cytology
Description

UAS drives expression of the entire mRNA sequence of the transcription factor "α1ACT" (with its native start and stop codons), which is one product of the bicistronic Hsap\CACNA1A gene. The CAG repeat/polyQ region that is linked to spinocerebellar ataxia type 6 occurs within α1ACT, and this construct contains a non-pathogenic, wild-type version of 11 repeats. (The normal CAG repeat is between 4 and 18.)

(Tsou et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\CACNA1A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Hsap\CACNA1AUAS.αACT.Q11 under the control of Scer\GAL4sqh.PW does not lead to defects in lifespan. Scer\GAL4GMR.PU-driven expression does not induce major signs of retinal degeneration.

      (Tsou et al., 2016)

      Expression of Hsap\CACNA1AScer\UAS.αACT.Q11 driven by Scer\GAL4sqh.PW, Scer\GAL4elav.PU, Scer\GAL4Mef2.PU or Scer\GAL4repo.PU does not significantly affect lifespan compared to controls. Expression of Hsap\CACNA1AScer\UAS.αACT.Q11 driven by Scer\GAL4GMR.PU does not cause clear or progressive anomalies in the retina. A more sensitive GFP-based method shows that expression of Hsap\CACNA1AScer\UAS.αACT.Q11 driven by Scer\GAL4GMR.PU is mildly progressively toxic in fly eyes (significant loss at day 7 and 14 but not day 1).

      (Tsou et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\CACNA1AScer\UAS.αACT.Q11
      Hsap\CACNA1AUAS.αACT.Q11
      Name Synonyms
      Secondary FlyBase IDs
        References (2)