FB2026_02 , released June 18, 2026
Allele: Dmel\ProsapUASp.cHa
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General Information
Symbol
Dmel\ProsapUASp.cHa
Species
D. melanogaster
Name
FlyBase ID
FBal0319810
Feature type
allele
Associated gene
Dmel\Prosap
Associated Insertion(s)
Carried in Construct
P{UASp-Prosap.H}
Key Links
Transgenic product class
cDNA
(Harris et al., 2016)
wild_type
(Harris et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Harris et al., 2016)
wild_type
(Harris et al., 2016)
Mutagen
in vitro construct
(Harris et al., 2016)
Progenitor genotype
Carried in construct
P{UASp-Prosap.H}
Cytology
Description

UASp regulatory sequences drive expression of the full-length Prosap LD13733 cDNA.

(Harris et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Prosap
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ProsapScer\UAS.P\T.cHa under the control of Scer\GAL4Mef2.PR in third instar larvae results in a reduction in the number of synaptic boutons per NMJ, and an abnormally high number of Ghost boutons per NMJ, measured in NMJs of muscle 6/7, as compared with controls.

      Expression of ProsapScer\UAS.P\T.cHa under the control of Scer\GAL4how-24B in third instar larvae results in a reduction in the number of synaptic boutons per NMJ, but no significant difference in number of Ghost boutons per NMJ, measured in NMJs of muscle 6/7, as compared with controls.

      Expression of ProsapScer\UAS.P\T.cHa under the control of Scer\GAL4elav-C155 does not result in any morphological abnormalities, as compared with controls.

      (Harris et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4how-24B/ProsapUASp.cHa partially rescues ProsapD101

      (Harris et al., 2016)
      Fails to rescue

      Scer\GAL4Mef2.PR/ProsapUASp.cHa fails to rescue ProsapD101

      (Harris et al., 2016)

      Scer\GAL4elav-C155/ProsapUASp.cHa fails to rescue ProsapD101

      (Harris et al., 2016)
      Comments

      Expression of ProsapScer\UAS.P\T.cHa under the control of Scer\GAL4Mef2.PR fails to rescue the morphology defects of ProsapD101/ProsapD101 mutants.

      Expression of ProsapScer\UAS.P\T.cHa under the control of Scer\GAL4how-24B partially rescues the total bouton number defect, and rescues the Ghost bouton number increase of ProsapD101/ProsapD101 mutants.

      Expression of ProsapScer\UAS.P\T.cHa under the control of Scer\GAL4elav-C155 fails to rescue the morphology defects of ProsapD101/ProsapD101 mutants.

      (Harris et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ProsapScer\UAS.P\T.cHa
      ProsapUASp.cHa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)