FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pcl3-78.38
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General Information
Symbol
Dmel\Pcl3-78.38
Species
D. melanogaster
Name
FlyBase ID
FBal0320064
Feature type
allele
Associated gene
Dmel\Pcl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Apitz and Salecker, 2016)
Progenitor genotype
Cytology
Description

Amino acid replacement: W536term.

(Apitz and Salecker, 2016)

Nucleotide substitution: G?A.

(Apitz and Salecker, 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:18,137,589..18,137,589 [+]
Nucleotide change:

G18137589A

Reported nucleotide change:

G?A

Amino acid change:

W536term | Pcl-PA; W536term | Pcl-PB

Reported amino acid change:

W536term

Comment:

Mutation in codon W536 (TGG to TAG).

(Apitz and Salecker, 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Somatic clones of homozygous mutant cells induced specifically in brain optic lobes show large ectopic clusters of Fas3-positive outer proliferation centre (OPC)-derived cells with inner proliferation centre (IPC)-like identity which do not generate neuroblasts. These large clones form in the lobula plate area during post-embryonic development and persist to adulthood (additionally, small Fas3 positive clones accumulate in close vicinity of OPC). The clusters do not show any significant increase in mitotic activity compared to wild-type OPC neuroepithelial cells in third instar stage larvae.

      Pcl3-78.38/Pcl3-78.38 mutant migratory progenitors in somatic MARCM clones in the IPC of third instar larval brain optic lobes prematurely differentiate into neuroblasts.

      (Apitz and Salecker, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Abd-BGD4680 RNAi under the control of Scer\GAL4lama-A8 in the Pcl3-78.38 homozygous mutant somatic clones induced specifically in brain optic lobes prevents the formation of Fas3-positive cell clusters characteristic for Pcl3-78.38 clones.

      (Apitz and Salecker, 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Separable from: two secondary lethal mutations (at 43A4--43D3 and 50A1--50A7 respectively) on the same chromosome.

      (Apitz and Salecker, 2016)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      3-78
      (Apitz and Salecker, 2016)
      Pcl3-78*38
      (Apitz and Salecker, 2016)
      Pcl3-78.38
      Name Synonyms
      Secondary FlyBase IDs
        References (1)