FlyBase Allele Report: Dmel\Git[UAS.cPa]

General Information

Symbol

Dmel\Git^UAS.cPa

Species

D. melanogaster

Name

FlyBase ID

FBal0320068

Feature type

allele

Associated gene

Dmel\Git

Associated Insertion(s)

Carried in Construct

P{UAS-Git.P}

Key Links

Transgenic product class

cDNA

(Podufall et al., 2014)

wild_type

(Podufall et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Podufall et al., 2014)

wild_type

(Podufall et al., 2014)

Mutagen

in vitro construct

(Podufall et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-Git.P}

Cytology

Description

UAS regulatory sequences drive expression of a Git cDNA.

(Podufall et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Git

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^elav-C155/Git^UAS.cPa rescues Git^f03586/Git^ex10

(Podufall et al., 2014)

Scer\GAL4^RapGAP1-OK6/Git^UAS.cPa rescues Git^f03586/Git^ex10

(Podufall et al., 2014)

Scer\GAL4^RapGAP1-OK6/Git^UAS.cPa rescues Git^ex10/Df(2R)BSC596

(Podufall et al., 2014)

Comments

Expression of Git^Scer\UAS.cPa driven by Scer\GAL4^elav-C155 rescues climbing defects seen in Git^ex10/Git^f03586 flies. Expression of Git^Scer\UAS.cPa driven by Scer\GAL4^RapGAP1-OK6 rescues enlarged postsynaptic glutamate receptor fields and reduced eEJCs seen at the NMJ in Git^ex10/Git^f03586 third instar larvae. Expression of Git^Scer\UAS.cPa driven by Scer\GAL4^elav-C155 rescues increased endosome area per bouton seen at the NMJ in Git^ex10/Git^f03586 third instar larvae. Expression of Git^Scer\UAS.cPa or Git^{Scer\UAS.cPa.T:Avic\GFP-EGFP} driven by Scer\GAL4^RapGAP1-OK6 rescues synaptic vesicle recycling defects at the NMJ in Git^ex10/Git^f03586 or Git^ex10/Df(2R)BSC596 third instar larvae.

(Podufall et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Git^Scer\UAS.cPa

Git^UAS.cPa

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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