FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pmm2FS2
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General Information
Symbol
Dmel\Pmm2FS2
Species
D. melanogaster
Name
FlyBase ID
FBal0320426
Feature type
allele
Associated gene
Dmel\Pmm2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Parkinson et al., 2016)
Mutagen
CRISPR/Cas9
(Parkinson et al., 2016)
Progenitor genotype
Cytology
Description

Frameshift mutation.

(Parkinson et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  congenital disorder of glycosylation type I
      CEA
      (Parkinson et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pmm2FS1/Pmm2FS2 and Pmm2FS2/Df(3L)BSC380 mutants show early larval lethality during the late first to early second instar transition.

      Pmm2FS2/Pmm2FS2 mutant first instar larvae display a significant reduction in coordinated movement compared to wild type, as measured by rate of peristaltic waves; first instar muscle 4 neuromuscular junctions prior to developmental arrest display over-elaboration, with more branches, greater synaptic terminal area, and supernumerary type Is/Ib synaptic boutons, as compared to controls.

      (Parkinson et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pmm2FS2
      pmm2FS2
      (Parkinson et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)