FB2026_02 , released June 18, 2026
Allele: Dmel\Kap-α3UAS.Tag:HA
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General Information
Symbol
Dmel\Kap-α3UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0321375
Feature type
allele
Associated gene
Dmel\Kap-α3
Associated Insertion(s)
Carried in Construct
P{UAS-HA-Kap-α3}
Key Links
Transgenic product class
cDNA
(Sachan et al., 2013)
wild_type
(Sachan et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Sachan et al., 2013)
wild_type
(Sachan et al., 2013)
Mutagen
in vitro construct
(Sachan et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-HA-Kap-α3}
Cytology
Description

UASt regulatory sequences drive expression of a full-length Kap-α3 cDNA that is tagged at the N-terminal end with Tag:HA.

(Sachan et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Kap-α3
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Kap-α3Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4en.PU leads to N protein accumulation: cytoplasmic aggregates of the N protein are observed in the posterior compartment of the disc. Kap-α3Scer\UAS.T:Ivir\HA1 expression driven by Scer\GAL4ey.PU does not perturb either eye disc morphology in third instar larvae or ommatidial structure in the adult eye.

      (Sachan et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The adult eye defects - irregularities in size and spacing of ommatidia and aberrant numbers of interommatidial bristles - as well as decreased eclosion rate and reduced adult life-span observed in flies expressing NICN.Scer\UAS under the control of Scer\GAL4ey.PU is exacerbated further by co-expression of Kap-α3Scer\UAS.T:Ivir\HA1. The neoplastic overgrowth of both eye and wing discs induced by NICN.Scer\UAS expression (controlled by either the Scer\GAL4ey.PU or the Scer\GAL4ap.PU driver, respectively) is also strongly enhanced by Kap-α3Scer\UAS.T:Ivir\HA1 co-expression.

      (Sachan et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Kap-α3Scer\UAS.T:Ivir\HA1
      Kap-α3UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)