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General Information
Symbol
Dmel\TorsindsRNA.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0321718
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASp sequences regulate expression of two copies of the second exon of Torsin cloned in a tail-to-tail configuration separated by a 70 bp spacer, which mediates RNAi against the Torsin transcript.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of TorsindsRNA.Scer\UAS.P\T driven by Scer\GAL4GMR.PF results in a weak rough eye (disorganized retinas) phenotype compared to controls; additional presence of Df(1)bi-DL2 results in a slightly stronger phenotype (though Df(1)bi-DL2/+ alone does not have a rough eye phenotype). At 4 and 7 weeks old, Df(1)bi-DL2/+;Scer\GAL4GMR.PF>TorsindsRNA.Scer\UAS.P\T flies show a widespread significant increase in degenerative spots (holes) on the retina, compared to controls (holes are also significantly increased from 4 to 7 weeks old in mutants). Expression of TorsindsRNA.Scer\UAS.P\T driven by Scer\GAL4GMR.PF results in thickening of pigment granule areas in the retina (38% penetrance) and disorganized pigment granule patterns with occasional gaps or accumulations; remaining retinas do not show a clear thickening phenotype, but show disorganized granule patterns and additional presence of Df(1)bi-DL2 results in stronger phenotypes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
TorsindsRNA.Scer\UAS.P\T
TorsindsRNA.UASp
Name Synonyms
Secondary FlyBase IDs
    References (1)