FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TorsinUASp.gen
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General Information
Symbol
Dmel\TorsinUASp.gen
Species
D. melanogaster
Name
FlyBase ID
FBal0321719
Feature type
allele
Associated gene
Dmel\Torsin
Associated Insertion(s)
Carried in Construct
P{UASp-Torsin.gen}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Muraro and Moffat, 2006)
Progenitor genotype
Carried in construct
P{UASp-Torsin.gen}
Cytology
Description

UASp sequences regulate expression of a 1.5 Kb genomic fragment containing Torsin.

(Muraro and Moffat, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Torsin
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Over-expression of TorsinScer\UAS.P\T.gen driven by Scer\GAL4GMR.PF results in a weak rough eye phenotype (disorganized retinas) and defects in pigment granule organization (loss of pigment granules, thinning of interommatidial pigment areas) compared to controls. 7 week old Scer\GAL4GMR.PF>TorsinScer\UAS.P\T.gen flies show reduced degeneration (fewer holes in the retina) compared to controls, along with areas with loss of pigments and severe loss of interommatidial pigment granules. Scer\GAL4GMR.PF>TorsinScer\UAS.P\T.gen pupal retinas have a normal lattice of cells including correct pigment cell positioning.

      (Muraro and Moffat, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TorsinScer\UAS.P\T.gen
      TorsinUASp.gen
      Name Synonyms
      Secondary FlyBase IDs
        References (2)