FlyBase Allele Report: Dmel\mdy[HMC06242]

General Information

Symbol

Dmel\mdy^HMC06242

Species

D. melanogaster

Name

FlyBase ID

FBal0322494

Feature type

allele

Associated gene

Dmel\mdy

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC06242}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMC06242}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC06242

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile, with Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

Phenotype Manifest In

embryonic/larval garland cell | third instar larval stage, with Scer\GAL4^Ugt36A1.PK

(Marchesin et al., 2019)

lipid droplet | third instar larval stage, with Scer\GAL4^Ugt36A1.PK

(Marchesin et al., 2019)

Detailed Description

Statement

Reference

Expressing mdy^HMC06242 under the control of Scer\GAL4^Ugt36A1.PK induces a decrease in lipid droplet content (BODIPY staining) in third instar larval garland nephrocytes, as compared to controls.

(Marchesin et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^Ugt36A1.PK, mdy^HMC06242 has lipid droplet | third instar larval stage phenotype, suppressible | partially by Hnf4^JF02539, Scer\GAL4^Ugt36A1.PK

(Marchesin et al., 2019)

Scer\GAL4^Ugt36A1.PK, mdy^HMC06242 has embryonic/larval garland cell | third instar larval stage phenotype, suppressible | partially by Hnf4^JF02539, Scer\GAL4^Ugt36A1.PK

(Marchesin et al., 2019)

NOT suppressed by

Statement

Reference

Scer\GAL4^Ugt36A1.PK, mdy^HMC06242 has lipid droplet | third instar larval stage phenotype, non-suppressible by Hnf4^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^Ugt36A1.PK

(Marchesin et al., 2019)

Scer\GAL4^Ugt36A1.PK, mdy^HMC06242 has embryonic/larval garland cell | third instar larval stage phenotype, non-suppressible by Hnf4^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^Ugt36A1.PK

(Marchesin et al., 2019)

NOT Enhancer of

Statement

Reference

mdy^HMC06242, Scer\GAL4^ninaE.PT is a non-enhancer of photoreceptor neuron | adult stage phenotype of Lsd-1^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

mdy^HMC06242, Scer\GAL4^ninaE.PT is a non-enhancer of lipid droplet | adult stage | increased number phenotype of Lsd-1^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Suppressor of

Statement

Reference

mdy^HMC06242, Scer\GAL4^Ugt36A1.PK is a suppressor of lipid droplet | third instar larval stage phenotype of Hnf4^JF02539, Scer\GAL4^Ugt36A1.PK

(Marchesin et al., 2019)

mdy^HMC06242, Scer\GAL4^Ugt36A1.PK is a suppressor of embryonic/larval garland cell | third instar larval stage phenotype of Hnf4^JF02539, Scer\GAL4^Ugt36A1.PK

(Marchesin et al., 2019)

mdy^HMC06242, Scer\GAL4^Ugt36A1.PK is a suppressor of lipid droplet | third instar larval stage phenotype of Hnf4^{R167W.UAS.Tag:HA}, Scer\GAL4^Ugt36A1.PK

(Marchesin et al., 2019)

mdy^HMC06242, Scer\GAL4^Ugt36A1.PK is a suppressor of embryonic/larval garland cell | third instar larval stage phenotype of Hnf4^{R167W.UAS.Tag:HA}, Scer\GAL4^Ugt36A1.PK

(Marchesin et al., 2019)

NOT Suppressor of

Statement

Reference

mdy^HMC06242, Scer\GAL4^ninaE.PT is a non-suppressor of photoreceptor neuron | adult stage phenotype of Lsd-1^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

mdy^HMC06242, Scer\GAL4^ninaE.PT is a non-suppressor of lipid droplet | increased number | adult stage phenotype of Lsd-1^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Other

Statement

Reference

Additional Comments

Genetic Interactions

Statement

Reference

Co-expressing mdy^HMC06242 and Hnf4^{UAS.ORF.GW.Tag:HA} under the control of Scer\GAL4^Ugt36A1.PK abolishes lipid droplets in third instar larval garland nephrocytes in both high (29[o]C) and low (18[o]C) Hnf4^{UAS.ORF.GW.Tag:HA} expressing conditions.

Co-expressing mdy^HMC06242 and Hnf4^{R167W.UAS.Tag:HA} under the control of Scer\GAL4^Ugt36A1.PK abolishes lipid droplets in third instar larval garland nephrocytes.

(Marchesin et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

65963

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06242}attP40/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mdy^HMC06242

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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