FlyBase Allele Report: Hsap\HSPA1L[K71E.UAS.sec]

General Information

Symbol

Hsap\HSPA1L^K71E.UAS.sec

Species

H. sapiens

Name

FlyBase ID

FBal0322577

Feature type

allele

Associated gene

Hsap\HSPA1L

Associated Insertion(s)

Carried in Construct

P{UAS-hHSPA1L.K71E.sec}

Key Links

Transgenic product class

missense_variant

(Fernandez-Funez et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Fernandez-Funez et al., 2016)

Mutagen

in vitro construct

(Fernandez-Funez et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-hHSPA1L.K71E.sec}

Cytology

Description

UAS regulatory sequences drive expression of the human Ig heavy chain V-III signal peptide followed by an ATPase-dead form of Hsap\HSPA1L (carries the amino acid replacement K71E). The resulting protein is secreted into the extracellular space.

(Fernandez-Funez et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\HSPA1L

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^2xAPP.SP.UAS

(Fernandez-Funez et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies expressing Hsap\HSPA1L^{K71E.Scer\UAS.sec} under the control of Scer\GAL4^GMR.PU do not exhibit any obvious eye phenotypes.

(Fernandez-Funez et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU is a suppressor of increased cell death | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU is a suppressor of abnormal size | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU is a suppressor of ommatidium | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU is a suppressor of lens phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\HSPA1L^{K71E.Scer\UAS.sec} completely suppresses the eye phenotypes of adult flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Fernandez-Funez et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\HSPA1L^{K71E.Scer\UAS.sec}

Hsap\HSPA1L^K71E.UAS.sec

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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