FlyBase Allele Report: Dmel\sona[13]

General Information

Symbol

Dmel\sona¹³

Species

D. melanogaster

Name

FlyBase ID

FBal0322716

Feature type

allele

Associated gene

Dmel\sona

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Kim et al., 2016)

Progenitor genotype

P{GawB}sona^NP5284

(Kim et al., 2016)

Cytology

Description

A spontaneous mutation recovered during a imprecise excision screen - the progenitor P-element is incompletely excised.

(Kim et al., 2016)

Amino acid replacement: W344term.

(Kim et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:23,767,414..23,767,414 [-]

Nucleotide change:

G23767414A

Amino acid change:

Reported amino acid change:

W344term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kim et al., 2016)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of P-stage

(Kim et al., 2016)

visible

(Kim et al., 2016)

visible (with sona¹⁸)

(Kim et al., 2016)

visible (with sona⁴⁷)

(Kim et al., 2016)

Phenotype Manifest In

arista

(Kim et al., 2016)

femur

(Kim et al., 2016)

interommatidial bristle

(Kim et al., 2016)

interommatidial bristle (with sona¹⁸)

(Kim et al., 2016)

interommatidial bristle (with sona⁴⁷)

(Kim et al., 2016)

unguis

(Kim et al., 2016)

wing blade

(Kim et al., 2016)

wing margin bristle

(Kim et al., 2016)

Detailed Description

Statement

Reference

sona¹³ homozygous mutants exhibit lethality throughout larval and pupal stages although rare escapers reach adulthood at a very low frequency (<1%) and these display various developmental defects: missing or malformed branches in their aristae, disoriented interommatidial bristles in the dorsal eye, crumpled and smaller wings with missing wing margin bristles, they often have kinks in the femur and occasionally also lack the tarsal claw.

sona¹³/sona⁴⁷ as well as sona¹³/sona¹⁸ heterozygous adults have disoriented interommatidial bristles especially in the dorsal eye.

(Kim et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sona¹³

(Kim et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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