FB2026_02 , released June 18, 2026
Allele: Dmel\PolG1KO
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General Information
Symbol
Dmel\PolG1KO
Species
D. melanogaster
Name
FlyBase ID
FBal0323340
Feature type
allele
Associated gene
Dmel\PolG1
Associated Insertion(s)
TI{TI}PolG1KO
Carried in Construct
Also Known As
DmPOLγA KO
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Bratic et al., 2015)
Mutagen
ends-out gene targeting
(Bratic et al., 2015)
Progenitor genotype
Associated Insertion(s)
TI{TI}PolG1KO
Cytology
Description

The tam transcription unit has been deleted and replaced by a short attP site.

(Bratic et al., 2015)
Allele components
Component
Use(s)
Also carries
attP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:13,823,980..13,827,930 [-]
Comment:

The PolG1 transcription unit has been deleted and replaced with an attP site by targeted homologous recombination.

(Bratic et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tamKO/+ flies develop normally to adulthood, but tamKO/tamKO flies exhibit complete lethality, dying at the third instar stage with a severe reduction in body weight.

      tamKO/tamQ1009A and tamKO/tamH1038A mutants exhibit lethality, with most individuals dying in the third instar larval stage, and the remainder dying during pupal stage; and larvae exhibit a significant decrease in body weight, as compared to controls.

      tamKO/tamD263A mutants exhibit an increase in lethality as compared to controls, with only around 20% surviving to adulthood, but do not exhibit a significant difference in body weight, as compared to controls.

      (Bratic et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      DmPOLγA KO
      (Bratic et al., 2015)
      DmPolγA KO
      (Siibak et al., 2017)
      PolG1KO
      tamKO
      (Chiang et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)