FlyBase Allele Report: Dmel\Galk[ΔEXC9]

General Information

Symbol

Dmel\Galk^ΔEXC9

Species

D. melanogaster

Name

FlyBase ID

FBal0323488

Feature type

allele

Associated gene

Dmel\Galk

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Jumbo-Lucioni et al., 2014)

Mutagen

P-element activity

(Jumbo-Lucioni et al., 2014)

Progenitor genotype

P{EPgy2}CG5068^EY03791

(Jumbo-Lucioni et al., 2014)

Caused by aberration

Df(3L)Galk^ΔEXC9

Cytology

Description

Imprecise excision of P{EPgy2}CG5068^EY03791 results in a 2990bp deletion that includes partial deletion of CG5068 and Galk.

(Daenzer et al., 2016)

A null (undetectable enzymatic activity) generated by imprecise excision of P{EPgy2}CG5068^EY03791.

(Jumbo-Lucioni et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:8,983,781..8,986,770 [-]

Comment:

Estimated boundaries of a 2990 bp deletion resulting from the imprecise excision of P{EPgy2}CG5068^EY03791 reported to extend from the site of the P insertion into Galk.

(Daenzer et al., 2016)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates galactosemia

modeled by Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Galk^ΔEXC9/Galk^ΔEXC9 mutant L3 larvae do not exhibit defects in rolling movement or NMJ structure, as compared to controls.

(Jumbo-Lucioni et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Galk^ΔEXC9/Galk^ΔEXC9 is a suppressor of abnormal locomotor behavior | third instar larval stage phenotype of Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

Galk^ΔEXC9/Galk^ΔEXC9 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

Galk^ΔEXC9/Galk^ΔEXC9 is a suppressor of NMJ bouton | third instar larval stage phenotype of Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

Galk^ΔEXC9/Galk^ΔEXC9 is a suppressor of synapse | third instar larval stage phenotype of Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

Galk^ΔEXC9/Galk^ΔEXC9 is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Galk^ΔEXC9/Galk^ΔEXC9 suppresses the rolling movement defects and NMJ over-elaboration phenotypes seen in Galt^Δ1AP2/Galt^Δ1AP2 mutant larvae.

(Jumbo-Lucioni et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

93186

w^*; Kr^If-1/CyO; Df(3L)Galk^ΔEXC9, Galk^ΔEXC9/TM6B, Tb¹

604342

w^*; P{Tub-GALDAR2}2 P{UAS-RedStinger}4/CyO; Df(3L)Galk^ΔEXC9, Galk^ΔEXC9/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Galk^DeltaEXC9

(Sakizli et al., 2024)

Galk^ΔEXC9

dGALK^exc9

(Daenzer et al., 2016)

dGALK^ΔEXC9

(Jumbo-Lucioni et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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