FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\LRRK2KD.UAS
Open Close
General Information
Symbol
Hsap\LRRK2KD.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0323549
Feature type
allele
Associated gene
Hsap\LRRK2
Associated Insertion(s)
Carried in Construct
P{UAS-hLRRK2.KD}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Imai et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-hLRRK2.KD}
Cytology
Description

UASt regulatory sequences drive expression of a kinase-dead mutant form of Hsap\LRRK2.

(Imai et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\LRRK2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease 8
      CEA
      (Imai et al., 2015)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Scer\GAL4dpp.PU/Hsap\LRRK2KD.UAS is an enhancer of visible | adult stage phenotype of neurΔRING.UAS.EGFP

      (Imai et al., 2015)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Scer\GAL4dpp.PU/Hsap\LRRK2KD.UAS is an enhancer of wing margin phenotype of neurΔRING.UAS.EGFP

      (Imai et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The wing notching phenotype characteristic for adults expressing neurΔRING.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4dpp.PU is exacerbated by co-expression of Hsap\LRRK2KD.Scer\UAS.

      (Imai et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\LRRK2KD.Scer\UAS
      Hsap\LRRK2KD.UAS
      hLRRK2KD
      (Imai et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)