FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\His2AvKO
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General Information
Symbol
Dmel\His2AvKO
Species
D. melanogaster
Name
FlyBase ID
FBal0323577
Feature type
allele
Associated gene
Dmel\His2Av
Associated Insertion(s)
TI{TI}His2AvKO
Carried in Construct
Also Known As
H2AvKO
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Pengelly et al., 2015)
Mutagen
ends-out gene targeting
(Pengelly et al., 2015)
Progenitor genotype
Associated Insertion(s)
TI{TI}His2AvKO
Cytology
Description

The entire coding region (BDGP R6 chr3R: 26,866,929-26,869,220) of His2Av is replaced by a "mini-white" marker.

(Pengelly et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:26,866,929..26,869,220 [+]
Comment:

Entire His2Av gene has been deleted and replaced with a "mini-white" marker.

(Pengelly et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      His2AvKO homozygotes do not survive to late larval stages, and have very small imaginal discs.

      Imaginal disc clones of His2AvKO homozygous cells do not survive.

      (Müller, 2016.10.7)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      H2AvKO
      (Chen et al., 2025, Müller, 2016.10.7, Pengelly et al., 2015)
      His2AvKO
      Name Synonyms
      Secondary FlyBase IDs
        References (3)