FB2026_03 , released September 17, 2026
Allele: Dmel\Apc2AA
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General Information
Symbol
Dmel\Apc2AA
Species
D. melanogaster
Name
FlyBase ID
FBal0324259
Feature type
allele
Associated gene
Dmel\Apc2
Associated Insertion(s)
Carried in Construct
P{Apc2.AA}
Key Links
Transgenic product class
missense_variant
(Pronobis et al., 2015)
polypeptide_post_translational_processing_variant
(Pronobis et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Pronobis et al., 2015)
polypeptide_post_translational_processing_variant
(Pronobis et al., 2015)
Mutagen
in vitro construct
(Pronobis et al., 2015)
Progenitor genotype
Carried in construct
P{Apc2.AA}
Cytology
Description

The endogenous Apc promoter drives expression of a mutated form of Apc2 : two of the conserved Ser residues in the potential GSK3 phosphorylation site of region B have been mutated to Ala, preventing phosphorylation at these residues.

(Pronobis et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
Apc2
Encoded product / tool
Apc2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Apc2AA partially rescues Apc2g10

      (Pronobis et al., 2015)
      Comments

      The embryonic lethality along with cuticle defects (loss of denticles, expansion of naked cuticle) characteristic for maternal/zygotic Apc2g10,ApcQ8 mutants is only weakly rescued by combination with Apc2AA.

      (Pronobis et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Apc2AA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)