FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Chchd3D1
Open Close
General Information
Symbol
Dmel\Chchd3D1
Species
D. melanogaster
Name
FlyBase ID
FBal0324696
Feature type
allele
Associated gene
Dmel\Chchd3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Deng et al., 2016)
Mutagen
P-element activity
(Deng et al., 2016)
Progenitor genotype
P{PZ}Chchd303670
(Deng et al., 2016)
Cytology
Description

Imprecise excision of P{PZ}Chchd303670 results in a 1069bp deletion (from Ch3R: 31,052,786 to Ch3R: 31,053,854), removing a large portion of the Chchd3 coding region (including the translation start site and amino terminal 226 codons).

(Deng et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:31,052,786..31,053,854 [-]
Comment:

A 1069 bp deletion resulting from the imprecise excsion of P{PZ}Chchd303670 removes most of the Chchd3 coding region. The genome coordinates of the breakpoints were reported as 3R:31052786..31053854 .

(Deng et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Chchd3D1 homozygous as well as Chchd3D1/Df(3R)BSC749 transheterozygous mutants are lethal, display growth defects and arrest at second instar larval stage. Mitochondria of Chchd3D1 mutant larvae display morphological defects with reduced cristae content.

      Chchd3D1 mutant somatic clones are smaller compared to the twinspot clones due to decrease in proliferation (neither cell death level nor cell size is changed in the mutant clones) and display increased levels of oxidative stress markers.

      The size (normalized to the respective twinspots) of wtsx1;Chchd3D1 double mutant somatic clones in the wing disc is intermediate between the overgrowing wtsx1 clones and under-growing Chchd3D1 clones but larger than the control wild-type clones.

      (Deng et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Chchd3D1 is rescued by Chchd3UAS.cDa/Scer\GAL4Tub.PU

      (Deng et al., 2016)
      Comments

      The larval growth defects and lethality characteristic for Chchd3D1 homozygotes is rescued by expression of Chchd3Scer\UAS.cDa under the control of Scer\GAL4tub.PU in the mutant background.

      (Deng et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CHCHDD1
      (Birker et al., 2023)
      ChChd3D1
      (Deng et al., 2016)
      Chchd3D1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)