FlyBase Allele Report: Dmel\Mettl3[UAS.cLa.Tag:HA]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Mettl3^{UAS.cLa.Tag:HA}

General Information

Symbol

Dmel\Mettl3^{UAS.cLa.Tag:HA}

Species

D. melanogaster

Name

FlyBase ID

FBal0324794

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{UAS-Mettl3.HA}

Also Known As

UAS-Mettl3-HA

Key Links

Transgenic product class

(Lence et al., 2016)

(Lence et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Lence et al., 2016)

(Lence et al., 2016)

Mutagen

in vitro construct

(Lence et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-Mettl3.HA}

Cytology

Description

UAS regulates expression of Tag:HA-tagged Mettl3 cDNA.

(Lence et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Tagged with

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Mettl3^{UAS.cLa.Tag:HA}/Scer\GAL4^elav.PLu is a non-suppressor of decreased efficacy of short-term memory | adult stage | progressive phenotype of Df(3R)BSC461/Ythdf^NP3

(Kan et al., 2021)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Mettl3^{UAS.cLa.Tag:HA}/Scer\GAL4^elav.PLu rescues Mettl3^Δcat/Mettl3^null

(Kan et al., 2021)

Scer\GAL4^Mef2.247/Mettl3^{UAS.cLa.Tag:HA} rescues Mettl3^Δcat/Mettl3^null

(Kan et al., 2021)

Scer\GAL4^elav-C155/Mettl3^{UAS.cLa.Tag:HA} rescues Mettl3^Δcat

(Lence et al., 2016)

Mettl3^{UAS.cLa.Tag:HA}/Scer\GAL4^Tub.PU rescues Mettl3^Δcat

(Lence et al., 2016)

Fails to rescue

Scer\GAL4^how-24B/Mettl3^{UAS.cLa.Tag:HA} fails to rescue Mettl3^Δcat

(Lence et al., 2016)

Comments

Expression of Ime4^{Scer\UAS.cLa.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 or Scer\GAL4^tub.PU, but not Scer\GAL4^how-24B, rescues the wing posture defects, activity levels, and reduced walking speed seen in Ime4^Δcat/Ime4^Δcat flies.

(Lence et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ime4^{Scer\UAS.cLa.T:Ivir\HA1}

Mettl3^{Scer\UAS.cLa.T:Ivir\HA1}

Mettl3^{UAS.cLa.Tag:HA}

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections