FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nrd1UAS.mCherry
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General Information
Symbol
Dmel\Nrd1UAS.mCherry
Species
D. melanogaster
Name
FlyBase ID
FBal0325005
Feature type
allele
Associated gene
Dmel\Nrd1
Associated Insertion(s)
Carried in Construct
PBac{UAS-Nrd1.mCherry}
Key Links
Transgenic product class
dominant_negative_variant
(Yoon et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Yoon et al., 2017)
Mutagen
in vitro construct
(Yoon et al., 2017)
Progenitor genotype
Carried in construct
PBac{UAS-Nrd1.mCherry}
Cytology
Description

UAS regulatory sequences drive expression of Nrd1 cDNA tagged with mCherry at the C-terminal; does not rescue loss of function mutations when expressed ubiquitously, and may act as a dominant negative.

(Yoon et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Nrd1
Tagged with
mCherry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Nrd1UAS.mCherry/Scer\GAL4da.G32 fails to rescue Nrd1R540X

      (Yoon et al., 2017)

      Nrd1UAS.mCherry/Scer\GAL4da.G32 fails to rescue Nrd1K134X

      (Yoon et al., 2017)

      Nrd1UAS.mCherry/Scer\GAL4da.G32 fails to rescue Nrd1W369X

      (Yoon et al., 2017)

      Nrd1UAS.mCherry/Scer\GAL4da.G32 fails to rescue Nrd1Q376X

      (Yoon et al., 2017)
      Comments

      The pupal lethality of any of the following mutants: Nrd1Q376X, Nrd1R540X, Nrd1W369X or Nrd1K134X cannot be rescued by expression of Nrd1Scer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4da.G32 in the mutant background.

      (Yoon et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nrd1Scer\UAS.T:Disc\RFP-mCherry
      Nrd1UAS.mCherry
      Name Synonyms
      Secondary FlyBase IDs
        References (1)