FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\botv2R24
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General Information
Symbol
Dmel\botv2R24
Species
D. melanogaster
Name
FlyBase ID
FBal0325431
Feature type
allele
Associated gene
Dmel\botv
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Lujan et al., 2016)
Mutagen
ethyl methanesulfonate
(Lujan et al., 2016)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q50term.

(Lujan et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:19,129,837..19,129,837 [+]
Nucleotide change:

C19129837T

Reported nucleotide change:

C?T

Amino acid change:

Q50term | botv-PA

Reported amino acid change:

Q50term

(Lujan et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      botv2R24 homozygotes and botv2R24/botv423 transheterozygotes are lethal; both botv2R24 maternal-zygotic homozygous embryos and botv2R24/botv423 transheterozygous embryos with botv2R24-homozygous maternal contribution display moderate cuticle defects, namely partially fused denticle belts while retaining some naked cuticle in each segment, as compared to controls.

      Mosaic eyes containing botv2R24 homozygous clones are smaller than wild-type control eyes containing wild-type clones.

      (Lujan et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      botv2R24
      (Lujan et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)