FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ctr9KO
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General Information
Symbol
Dmel\Ctr9KO
Species
D. melanogaster
Name
FlyBase ID
FBal0325445
Feature type
allele
Associated gene
Dmel\Ctr9
Associated Insertion(s)
TI{TI}Ctr9KO
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gene targeting by homologous recombination
(Chaturvedi et al., 2016)
Progenitor genotype
Associated Insertion(s)
TI{TI}Ctr9KO
Cytology
Description

The 3.6 kb coding sequence shared by both annotated isoforms of Ctr9 is replaced with a Disc\RFP/Kanamycin cassette.

(Chaturvedi et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ctr9KO/Df(3L)BSC250 transheterozygotes and Ctr9KO homozygotes are lethal.

      Mosaic germaria containing Ctr9KO germline or follicle stem cell clones are present at similar proportions over time, as compared to germaria containing control germline or follicle stem cell clones, respectively; Ctr9KO homozygous germline clones within the germarium do not exhibit obvious nuclear morphology defects and the resulting developing egg chambers display an apparently normal morphology up until mid-oogenesis, when they degenerate, as compared to controls; Ctr9KO follicle stem clones within developing egg chambers do not show any obvious phenotype, as compared to controls.

      (Chaturvedi et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Ctr9KO/Df(3L)BSC250 has lethal phenotype, suppressible by Scer\GAL4da.PU/Hsap\CTR9UAS.Tag:HA

      (Chaturvedi et al., 2016)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The lethality of Ctr9KO/Df(3L)BSC250 transheterozygotes is rescued by the expression of Hsap\CTR9Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4da.PU, but the resulting females are sterile despite laying eggs.

      (Chaturvedi et al., 2016)
      Complementation and Rescue Data
      Rescued by

      Ctr9KO/Df(3L)BSC250 is rescued by Ctr9UAS.cCa/Scer\GAL4da.PU

      (Chaturvedi et al., 2016)
      Comments

      The lethality of Ctr9KO/Df(3L)BSC250 transheterozygotes is rescued by the expression of Ctr9Scer\UAS.cCa under the control of Scer\GAL4da.PU.

      (Chaturvedi et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ctr9KO
      (Chaturvedi et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)