FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ctr9RNAi.UAS.1
Open Close
General Information
Symbol
Dmel\Ctr9RNAi.UAS.1
Species
D. melanogaster
Name
FlyBase ID
FBal0325446
Feature type
allele
Associated gene
Dmel\Ctr9
Associated Insertion(s)
Carried in Construct
M{UAS-Ctr9.RNAi.1}
Key Links
Transgenic product class
RNAi_reagent
(Chaturvedi et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Chaturvedi et al., 2016)
Mutagen
in vitro construct
(Chaturvedi et al., 2016)
Progenitor genotype
Carried in construct
M{UAS-Ctr9.RNAi.1}
Cytology
Description

UAS regulates expression of a shRNA targeting the final exon of Ctr9 (that is shared between transcripts RA and RB), made in the Valium 20 vector.

(Chaturvedi et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Ctr9
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Ctr9dsRNA.Scer\UAS.1 under the control of Scer\GAL4da.PU leads to lethality.

      The expression of Ctr9dsRNA.Scer\UAS.1 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16, in females reared under 25[o]C of temperature or reared under 18[o]C during development but shifted to 25[o]C after eclosion, leads to the progressive loss of germline cells from the germarium, the nuclei of which exhibit severe morphological defects and polyploidy, as compared to controls; the same expression in females reared under 18[o]C of temperature during development and adulthood leads to no obvious defects in the germarium, as compared to controls.

      (Chaturvedi et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The morphology defects in germarium nuclei induced by the expression of Ctr9dsRNA.Scer\UAS.1 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 is fully rescued by the co-expression of Hsap\CTR9Scer\UAS.T:Ivir\HA1.

      (Chaturvedi et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ctr9RNAi.UAS.1
      Ctr9dsRNA.Scer\UAS.1
      Ctr9dsRNA.UAS.1
      Name Synonyms
      Secondary FlyBase IDs
        References (3)