FB2026_02 , released June 18, 2026
Allele: Dmel\AGO2m1
Open Close
General Information
Symbol
Dmel\AGO2m1
Species
D. melanogaster
Name
FlyBase ID
FBal0325570
Feature type
allele
Associated gene
Dmel\AGO2
Associated Insertion(s)
Carried in Construct
P{AGO2.m1}
Key Links
Transgenic product class
missense_variant
(Chinen and Lei, 2017)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Chinen and Lei, 2017)
Mutagen
in vitro construct
(Chinen and Lei, 2017)
Progenitor genotype
AGO2+t10.15
(Chinen and Lei, 2017)
Carried in construct
P{AGO2.m1}
Cytology
Description

Site-directed mutagenesis (T1149A, Y1150A) of AGO2 (RP98-21A13 from BACPAC Resources Center) under the control of the endogenous promoter.

(Chinen and Lei, 2017)
Allele components
Component
Use(s)
Regulatory region(s)
AGO2
Encoded product / tool
AGO2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      AGO2m1 partially rescues AGO251B

      (Chinen and Lei, 2017)
      Comments

      The loss of RNA interference functionality characteristic for AGO251B mutants and manifested by their retaining red eye color upon expression of wdsRNA.GMR is only partially rescued by combination with AGO2m1 and results in light red eye color.

      (Chinen and Lei, 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      AGO2m1
      (Chinen and Lei, 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)