FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dsor1F53S.UASp
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General Information
Symbol
Dmel\Dsor1F53S.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0325706
Feature type
allele
Associated gene
Dmel\Dsor1
Associated Insertion(s)
Carried in Construct
P{UASp-Dsor1.F53S}
Key Links
Genomic Maps

Transgenic product class
gain_of_function_variant
(Jindal et al., 2017)
missense_variant
(Jindal et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
gain_of_function_variant
(Jindal et al., 2017)
missense_variant
(Jindal et al., 2017)
Mutagen
in vitro construct
(Goyal et al., 2017)
Progenitor genotype
Carried in construct
P{UASp-Dsor1.F53S}
Cytology
Description

UASp regulatory sequences drive expression of a constitutively active form of Dsor1.

(Goyal et al., 2017)

UASp regulatory sequences drive expression of Dsor1, carrying the activating mutation F53S.

(Jindal et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Dsor1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:9,248,646..9,248,646 [+]
Nucleotide change:

T9248646C

Amino acid change:

F72S | Dsor1-PA; F69S | Dsor1-PB

Comment:

Analogous mutation in human MEK1 implicated in RAS-related diseases; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change. F53 in human MEK1 aligns with F72 in Drosophila ortholog Dsor1.

(Goyal et al., 2017, Jindal et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  RASopathy
      CEA
      (Marmion et al., 2021)
      model of  cancer
      CEA
      (Jindal et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Goyal et al., 2017)
      MAP2K1:p.Phe53Ser
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: MAP2K1_13350
      Comments concerning this variant
      MAP2K2:p.Phe57Ser
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Dsor1F53S.Scer\UAS.P\T under the combined control of Scer\GAL4nos.UTR.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4otu.T:Hsim\VP16 leads to high embryonic lethality and morphological defects: their cuticles have less than eight segments and display loss of anterior head structures.

      (Goyal et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dsor1F53S.Scer\UAS.P\T
      Dsor1F53S.UASp
      MEKF53S
      (Goyal et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)