FlyBase Allele Report: Dmel\Dis3[HMS05761]

General Information

Symbol

Dmel\Dis3^HMS05761

Species

D. melanogaster

Name

FlyBase ID

FBal0326029

Feature type

allele

Associated gene

Dmel\Dis3

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS05761}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMS05761}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS05761

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of primary ovarian insufficiency

CEA

(Kline et al., 2025, Johnstone et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of primary ovarian insufficiency

is ameliorated by Hsap\DIS3^UAS.cKa

(Kline et al., 2025)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

female germline cell | absent, with Scer\GAL4^NP1624

(Kline et al., 2025)

female germline cell | absent, with Scer\GAL4^{VP16.nanos.UTR}

(Kline et al., 2025)

germarium | absent, with Scer\GAL4^{VP16.nanos.UTR}

(Kline et al., 2025)

oocyte | absent, with Scer\GAL4^{VP16.nanos.UTR}

(Kline et al., 2025)

oocyte | absent, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Johnstone et al., 2023)

ovariole | absent, with Scer\GAL4^{VP16.nanos.UTR}

(Kline et al., 2025)

ovary, with Scer\GAL4^NP1624

(Kline et al., 2025)

ovary, with Scer\GAL4^{VP16.mat.αTub67C}

(Lee et al., 2025)

ovary, with Scer\GAL4^{VP16.nanos.UTR}

(Kline et al., 2025)

ovary, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Johnstone et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Dis3^HMS05761, Hsap\DIS3^UAS.cKa, Scer\GAL4^NP1624 has abnormal size | oogenesis phenotype

(Kline et al., 2025)

Dis3^HMS05761, Hsap\DIS3^H774Y.UAS, Scer\GAL4^NP1624 has abnormal size | oogenesis phenotype

(Kline et al., 2025)

Phenotype Manifest In

Suppressed by

Statement

Reference

Dis3^HMS05761, Scer\GAL4^NP1624 has ovary phenotype, suppressible | partially by Hsap\DIS3^UAS.cKa, Scer\GAL4^NP1624

(Kline et al., 2025)

Dis3^HMS05761, Scer\GAL4^NP1624 has ovary phenotype, suppressible | partially by Hsap\DIS3^H774Y.UAS, Scer\GAL4^NP1624

(Kline et al., 2025)

Dis3^HMS05761, Scer\GAL4^{VP16.nanos.UTR} has ovary phenotype, suppressible by Hsap\DIS3^UAS.cKa, Scer\GAL4^{VP16.nanos.UTR}

(Kline et al., 2025)

Dis3^HMS05761, Scer\GAL4^{VP16.nanos.UTR} has ovary phenotype, suppressible by Hsap\DIS3^H774Y.UAS, Scer\GAL4^{VP16.nanos.UTR}

(Kline et al., 2025)

Other

Statement

Reference

Dis3^HMS05761, Hsap\DIS3^H774Y.UAS, Scer\GAL4^NP1624 has nurse cell phenotype

(Kline et al., 2025)

Dis3^HMS05761, Hsap\DIS3^H774Y.UAS, Scer\GAL4^NP1624 has egg chamber phenotype

(Kline et al., 2025)

Dis3^HMS05761, Hsap\DIS3^UAS.cKa, Scer\GAL4^NP1624 has polar follicle cell phenotype

(Kline et al., 2025)

Dis3^HMS05761, Hsap\DIS3^H774Y.UAS, Scer\GAL4^NP1624 has ovariole phenotype

(Kline et al., 2025)

Dis3^HMS05761, Hsap\DIS3^H774Y.UAS, Scer\GAL4^NP1624 has germarium phenotype

(Kline et al., 2025)

Dis3^HMS05761, Hsap\DIS3^H774Y.UAS, Scer\GAL4^NP1624 has nucleus | oogenesis phenotype

(Kline et al., 2025)

Dis3^HMS05761, Hsap\DIS3^UAS.cKa, Scer\GAL4^NP1624 has follicle cell phenotype

(Kline et al., 2025)

Dis3^HMS05761, Hsap\DIS3^UAS.cKa, Scer\GAL4^NP1624 has egg chamber phenotype

(Kline et al., 2025)

Dis3^HMS05761, Hsap\DIS3^UAS.cKa, Scer\GAL4^NP1624 has ovariole phenotype

(Kline et al., 2025)

Dis3^HMS05761, Hsap\DIS3^UAS.cKa, Scer\GAL4^NP1624 has germarium phenotype

(Kline et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

67919

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05761}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dis3^HMS05761

Dis3^RNAi

(Kline et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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